Structural polymorphism of a cytosine-rich DNA sequence forming i-motif structure: Exploring pH based biosensors.

@article{Ahmed2018StructuralPO,
  title={Structural polymorphism of a cytosine-rich DNA sequence forming i-motif structure: Exploring pH based biosensors.},
  author={Saami Ahmed and Mahima Kaushik and Swati Chaudhary and Shrikant Kukreti},
  journal={International journal of biological macromolecules},
  year={2018},
  volume={111},
  pages={
          455-461
        }
}
Sequence recognition and conformational polymorphism enable DNA to emerge out as a substantial tool in fabricating the devices within nano-dimensions. These DNA associated nano devices work on the principle of conformational switches, which can be facilitated by many factors like sequence of DNA/RNA strand, change in pH or temperature, enzyme or ligand interactions etc. Thus, controlling these DNA conformational changes to acquire the desired function is significant for evolving DNA… CONTINUE READING