Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs

@inproceedings{Mok2014StructuralPI,
  title={Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs},
  author={Sachel Mok and Kek-Yee Liong and Eng-How Lim and Ximei Huang and Lei Zhu and Peter Rainer Preiser and Zbynek Bozdech},
  booktitle={Molecular microbiology},
  year={2014}
}
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programmes around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline-based drugs is becoming critical. So far only few resistance markers have been identified from which only two transmembrane transporters namely PfMDR1 (an ATP-binding cassette transporter) and PfCRT (a drug-metabolite transporter… CONTINUE READING
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