Structural plasticity with preserved topology in the postsynaptic protein network.

@article{Blanpied2008StructuralPW,
  title={Structural plasticity with preserved topology in the postsynaptic protein network.},
  author={Thomas A. Blanpied and Justin M Kerr and Michael D. Ehlers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 34},
  pages={12587-92}
}
The size, shape, and molecular arrangement of the postsynaptic density (PSD) determine the function of excitatory synapses in the brain. Here, we directly measured the internal dynamics of scaffold proteins within single living PSDs, focusing on the principal scaffold protein PSD-95. We found that individual PSDs undergo rapid, continuous changes in morphology driven by the actin cytoskeleton and regulated by synaptic activity. This structural plasticity is accompanied by rapid fluctuations in… CONTINUE READING

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