Structural plasticity and catalysis regulation of a thermosensor histidine kinase.

  title={Structural plasticity and catalysis regulation of a thermosensor histidine kinase.},
  author={Daniela Albanesi and Mariana L. Mart{\'i}n and F Trajtenberg and Mar{\'i}a Cecilia Mansilla and Ahmed Haouz and Pedro M Alzari and Diego de Mendoza and Alejandro Buschiazzo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 38},
Temperature sensing is essential for the survival of living cells. A major challenge is to understand how a biological thermometer processes thermal information to optimize cellular functions. Using structural and biochemical approaches, we show that the thermosensitive histidine kinase, DesK, from Bacillus subtilis is cold-activated through specific interhelical rearrangements in its central four-helix bundle domain. As revealed by the crystal structures of DesK in different functional states… CONTINUE READING
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