Structural peptides of a nonenveloped virus are involved in assembly and membrane translocation.

@article{Chevalier2005StructuralPO,
  title={Structural peptides of a nonenveloped virus are involved in assembly and membrane translocation.},
  author={Christophe Chevalier and Marie Galloux and Jaume Pous and C{\'e}line Henry and J{\'e}r{\^o}me Alexandre Denis and Bruno Gg da Costa and Jorge Navaza and Jean Lepault and Bernard Delmas},
  journal={Journal of virology},
  year={2005},
  volume={79 19},
  pages={
          12253-63
        }
}
The capsid of infectious bursal disease virus (IBDV), a nonenveloped virus of the family Birnaviridae, has a T=13l icosahedral shell constituted by a single protein, VP2, and several disordered peptides, all derived from the precursor pVP2. In this study, we show that two of the peptides, pep11 and pep46, control virus assembly and cell entry. Deletion of pep11 or even simple substitution of most of its residues blocks the capsid morphogenesis. Removal of pep46 also prevents capsid assembly but… CONTINUE READING
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