Structural pathology underlying neuroendocrine dysfunction in schizophrenia.

  title={Structural pathology underlying neuroendocrine dysfunction in schizophrenia.},
  author={Morris B. Goldman and Lei Wang and Carly Wachi and Sheeraz Daudi and John T. Csernansky and Megan Marlow-O'Connor and Sarah K. Keedy and Ivan Omar Olguin Torres},
  journal={Behavioural brain research},
  volume={218 1},
Polydipsic hyponatremic schizophrenic (PHS) patients exhibit altered neuroendocrine activity that has been linked to their life-threatening water imbalance, as well as to impaired function and reduced volume of the anterior hippocampus. Polydipsic patients without hyponatremia (polydipsic normonatremic schizophrenics: PNS) exhibit similar, albeit less marked, changes in neuroendocrine activity and anterior hippocampal function, but not reduced anterior hippocampal volume. Indeed, reduced… CONTINUE READING