Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.

@article{Thirup2015StructuralOO,
  title={Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.},
  author={S\oren Thirup and Lan Bich Van and Tine K Nielsen and Charlotte Rohde Knudsen},
  journal={Journal of structural biology},
  year={2015},
  volume={191 1},
  pages={10-21}
}
Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches. All G-proteins require activation via exchange of GDP for GTP to carry out their respective tasks. Often, guanine-nucleotide exchange factors are essential to this process. During translation, EF-Tu:GTP transports aminoacylated tRNA to the ribosome. GTP is hydrolyzed during this process, and subsequent reactivation of EF-Tu is catalyzed by… CONTINUE READING
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