Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.

Abstract

Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches. All G-proteins require activation via exchange of GDP for GTP to carry out their respective tasks. Often, guanine-nucleotide exchange factors are essential to this process. During translation, EF-Tu:GTP… (More)
DOI: 10.1016/j.jsb.2015.06.011

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Cite this paper

@article{Thirup2015StructuralOO, title={Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.}, author={S\oren Thirup and Lan Bich Van and Tine Kragh Nielsen and Charlotte Rohde Knudsen}, journal={Journal of structural biology}, year={2015}, volume={191 1}, pages={10-21} }