Structural origins of the functional divergence of human insulin-like growth factor-I and insulin.

  title={Structural origins of the functional divergence of human insulin-like growth factor-I and insulin.},
  author={Andrzej M Brzozowski and Eleanor J. Dodson and Guy G. Dodson and Garib N. Murshudov and Chandra Verma and Johan P Turkenburg and Frederik M de Bree and Zbigniew Dauter},
  volume={41 30},
Human insulin-like growth factors I and II (hIGF-I, hIGF-II) are potent stimulators of cell and growth processes. They display high sequence similarity to both the A and B chains of insulin but contain an additional connecting C-domain, which reflects their secretion without specific packaging or precursor conversion. IGFs also have an extension at the C-terminus known as the D-domain. This paper describes four homologous hIGF-1 structures, obtained from crystals grown in the presence of the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Structural organization of binding determinants in the molecule of insulin-like growth factor-I (IGF-I)

Journal of Evolutionary Biochemistry and Physiology • 2010
View 7 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 51 references

Identification of a nonpeptide ligand that releases bioactive insulinlike growth factor-I from its Binding Protein complex

Liu, X.-J, +4 authors N. Ling
J Biol • 2001

Putative disulfideforming pathway of porcine insulin precursor during its refolding in vitro

Qiao, Z.-S, +3 authors Y.-M
Biochemistry • 2001

The interaction of insulin-like growth factor with N-terminal domain of IGFBP-5.EMBO

W. Żesławski, Beisel, +6 authors T. A. Holak
J. 20, • 2001

Solution structure of an active miniproinsulin, M2PI: interchain flexibility is crucial for insulin activity

Y. S. Cho, S. G. Chang, +3 authors K. S. Kim
J. Biochem. Mol. Biol • 2000

Structure and function of type 1 insulin-like growth factor receptor

T. E. Adams, V. C. Epa, T.P.J. Garret, C. W. Ward
Cell. Mol. Life Sci • 2000

Similar Papers

Loading similar papers…