Structural origins of fibrin clot rheology.

  title={Structural origins of fibrin clot rheology.},
  author={E A Ryan and Lyle F. Mockros and John W. Weisel and Laszlo Lorand},
  journal={Biophysical journal},
  volume={77 5},
The origins of clot rheological behavior associated with network morphology and factor XIIIa-induced cross-linking were studied in fibrin clots. Network morphology was manipulated by varying the concentrations of fibrinogen, thrombin, and calcium ion, and cross-linking was controlled by a synthetic, active-center inhibitor of FXIIIa. Quantitative measurements of network features (fiber lengths, fiber diameters, and fiber and branching densities) were made by analyzing computerized three… CONTINUE READING
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