Structural origins of aminoglycoside specificity for prokaryotic ribosomes.

@article{Lynch2001StructuralOO,
  title={Structural origins of aminoglycoside specificity for prokaryotic ribosomes.},
  author={Stephen R. Lynch and Joseph D. Puglisi},
  journal={Journal of molecular biology},
  year={2001},
  volume={306 5},
  pages={
          1037-58
        }
}
Aminoglycoside antibiotics, including paromomycin, neomycin and gentamicin, target a region of highly conserved nucleotides in the decoding region aminoacyl-tRNA site (A site) of 16 S rRNA on the 30 S subunit. Change of a single nucleotide, A1408 to G, reduces the affinity of many aminoglycosides for the ribosome; G1408 distinguishes between prokaryotic and eukaryotic ribosomes. The structures of a prokaryotic decoding region A-site oligonucleotide free in solution and bound to the… CONTINUE READING

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Correlations of the guanosine exchangeable and nonexchangeable base protons

  • Simorre, J.-P, G. R. Zimmermann, L. Mueller, A. Pardi
  • 1996
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