Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus.

@article{Nakamura1986StructuralOO,
  title={Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus.},
  author={Hisashi Nakamura and Tsuyoshi Morita and Chikako Sato},
  journal={Experimental cell research},
  year={1986},
  volume={165 2},
  pages={291-7}
}
In mammalian cells, it has been shown that adjacent multiple DNA replicons, termed a replicon cluster or a replicon domain, are replicated coordinately in a defined temporal order during the DNA synthetic (S) phase. However, no intranuclear structure of this replicon domain has been revealed in the nucleus labelled with [3H]thymidine at the limited resolution level of autoradiography. By immunofluorescent staining with antibody against 5-bromodeoxyuridine (BrdU), we succeeded in detecting novel… CONTINUE READING
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