Structural organization of the inactive X chromosome in the mouse

  title={Structural organization of the inactive X chromosome in the mouse},
  author={Luca Giorgetti and Bryan R. Lajoie and Ava C. Carter and Mikael Attia and Ye Zhan and Jin Xu and Chong Chen and Noam Kaplan and Howard Y Chang and Edith Heard and Job Dekker},
X-chromosome inactivation (XCI) involves major reorganization of the X chromosome as it becomes silent and heterochromatic. During female mammalian development, XCI is triggered by upregulation of the non-coding Xist RNA from one of the two X chromosomes. Xist coats the chromosome in cis and induces silencing of almost all genes via its A-repeat region, although some genes (constitutive escapees) avoid silencing in most cell types, and others (facultative escapees) escape XCI only in specific… CONTINUE READING
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