Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.

@article{Taylor1995StructuralOO,
  title={Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus.},
  author={Shirley M. Taylor and Sarah J. Freemantle and Richard G. Moran},
  journal={Cancer research},
  year={1995},
  volume={55 24},
  pages={6030-4}
}
The cytotoxicity, and probably the selectivity, of folate antimetabolites depend upon the expression of the enzyme folylpoly-gamma-glutamate synthetase in tumor cells. Evidence for the existence of multiple forms of this enzyme and the need to define the control mechanisms determinant of expression levels in normal and neoplastic cells has focused attention on the gene(s) encoding these forms. The organization of the genomic locus for the human folylpoly-gamma-glutamate synthetase (FPGS) gene… CONTINUE READING