Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

@article{Stahl1990StructuralOO,
  title={Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.},
  author={Joachim Stahl and David P. Gearing and Tracy A Willson and Melissa A Brown and Julie A. King and N. M. Gough},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 15},
  pages={8833-41}
}
Leukemia inhibitory factor, LIF, is a glycoprotein with multiple activities in both the adult and the embryo. LIF appears to be encoded by a unique gene in both mouse and man, although the 3'-untranslated region of the mouse LIF gene gives a complex hybridization pattern on Southern blots. The complete nucleotide sequences of both the murine and human LIF genes and their flanking regions (8.7 and 7.6 kilobase pairs, respectively) were determined and compared. Both genes comprise three exons… CONTINUE READING
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