Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.

@article{Bourges2004StructuralOO,
  title={Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.},
  author={Ingrid Bourges and Claire Ramus and B{\'e}n{\'e}dicte Mousson de Camaret and R{\'e}jane Beugnot and Claire Remacle and Pierre Cardol and G{\"o}tz Hofhaus and J. -P. Issartel},
  journal={The Biochemical journal},
  year={2004},
  volume={383 Pt. 3},
  pages={491-9}
}
Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. However, the way these events affect complex I assembly is poorly documented. To understand the effects of particular mutations in ND subunits on complex I assembly, we studied four human cell lines: ND4 non-expressing cells, ND5… CONTINUE READING
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