Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.

@article{Tillett2000StructuralOO,
  title={Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.},
  author={Daniel Tillett and Elke Dittmann and Marcel Erhard and Hans von D{\"o}hren and Thomas B{\"o}rner and Brett A Neilan},
  journal={Chemistry & biology},
  year={2000},
  volume={7 10},
  pages={753-64}
}
BACKGROUND Blooms of toxic cyanobacteria (blue-green algae) have become increasingly common in the surface waters of the world. Of the known toxins produced by cyanobacteria, the microcystins are the most significant threat to human and animal health. These cyclic peptides are potent inhibitors of eukaryotic protein phosphatases type 1 and 2A. Synthesized nonribosomally, the microcystins contain a number of unusual amino acid residues including the beta-amino polyketide moiety Adda (3-amino-9… CONTINUE READING
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