Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3.

@article{Messerle1992StructuralOE,
  title={Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3.},
  author={Martin Messerle and Bernd B{\"u}hler and G{\"u}nther M. Keil and Ulrich H. Koszinowski},
  journal={Journal of virology},
  year={1992},
  volume={66 1},
  pages={
          27-36
        }
}
We have previously defined ie3 as a coding region located downstream of the ie1 gene which gives rise to a 2.75-kb immediate-early (IE) transcript. Here we describe the structural organization of the ie3 gene, the amino acid sequence of the gene product, and some of the functional properties of the protein. The 2.75-kb ie3 mRNA is generated by splicing and is composed of four exons. The first three exons, of 300, 111, and 191 nucleotides (nt), are shared with the ie1 mRNA and are spliced to… CONTINUE READING

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