Structural nested models, g-estimation, and the healthy worker effect: the promise (mostly unrealized) and the pitfalls.


In this issue of EPIDEMIOLOGY, Chevrier et al apply G-estimation to estimate the effect of exposure to metalworking fluids when a healthy-worker survivor effect is present. This is the first application of G-estimation to this problem in the more than 20 years since G-estimation was first proposed. Like G-computation (or the G-formula), G-estimation has… (More)
DOI: 10.1097/EDE.0b013e318245f798