Structural modifications of DAPY analogues with potent anti-HIV-1 activity.

@article{Feng2009StructuralMO,
  title={Structural modifications of DAPY analogues with potent anti-HIV-1 activity.},
  author={Xiao-qing Feng and Yong-hong Liang and Zhao-Sen Zeng and Fen-er Chen and Jan Balzarini and C Pannecouque and Erik de Clercq},
  journal={ChemMedChem},
  year={2009},
  volume={4 2},
  pages={219-24}
}
A novel series of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety at the C4 position were designed, with all compounds exhibiting strong activity against wild-type HIV-1.A novel series of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety at the C4 position were synthesized and evaluated for their in vitro activity against HIV in MT-4 cells. All compounds exhibited strong activity against wild-type HIV-1. The most active compound showed activity against wild-type HIV… CONTINUE READING

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