Structural modification of serum vitamin D3-binding protein and immunosuppression in AIDS patients.

@article{Yamamoto1995StructuralMO,
  title={Structural modification of serum vitamin D3-binding protein and immunosuppression in AIDS patients.},
  author={Nobuto Yamamoto and V. R. Naraparaju and Srinivasa M. Srinivasula},
  journal={AIDS research and human retroviruses},
  year={1995},
  volume={11 11},
  pages={1373-8}
}
A serum glycoprotein, vitamin D3-binding protein (Gc protein), can be converted by beta-galactosidase of stimulated B lymphocytes and sialidase of T lymphocytes to a potent macrophage-activating factor (MAF), a protein with N-acetylgalactosamine as the remaining sugar moiety. Thus, Gc protein is a precursor for MAF. Treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generates an extremely high-titered MAF (GcMAF). When peripheral blood monocytes/macrophages of 46… CONTINUE READING