Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(IV)-oxo compounds.

Abstract

A structural synthetic model of the iron(IV)-oxo-halide active species of non-heme iron dependent halogenases is reported. Compounds with general formula [Fe(IV)(O)(X)(Pytacn)](+) (1-X, X = Cl, Br) have been prepared and characterized spectroscopically and chemically with regard to their oxidizing ability. 1-X performs hydrogen-atom abstraction of C-H bonds at reaction rates 2-3 times faster than the corresponding solvato dicationic species, thus modelling the first step in C-H functionalization taking place in natural halogenation.

DOI: 10.1039/c4cc03234a

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Cite this paper

@article{Planas2014StructuralMO, title={Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(IV)-oxo compounds.}, author={Oriol Planas and Martin Cl{\'e}mancey and J M Latour and Anna Company and Miquel Costas}, journal={Chemical communications}, year={2014}, volume={50 74}, pages={10887-90} }