Structural model of the Plasmodium falciparum thioredoxin reductase:a novel target for antimalarial drugs.


BACKGROUND Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropical countries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drug targets. Thioredoxin reductase is a promising antimalarial drug target. METHODS The Thioredoxin reductase enzyme of Plasmodium falciparum was characterized in silico and… (More)


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