Structural model for deoxycytidine deamination mechanisms of the HIV-1 inactivation enzyme APOBEC3G.


APOBEC3G (Apo3G) is a single-stranded DNA-dependent deoxycytidine deaminase, which, in the absence of the human immunodeficiency virus (HIV) viral infectivity factor, is encapsulated into HIV virions. Subsequently, Apo3G triggers viral inactivation by processively deaminating C-->U, with 3'-->5' polarity, on nascent minus-strand cDNA. Apo3G has a… (More)
DOI: 10.1074/jbc.M110.107987