Structural mimicry of a native protein by a minimized binding domain.

@article{Starovasnik1997StructuralMO,
  title={Structural mimicry of a native protein by a minimized binding domain.},
  author={Melissa A. Starovasnik and Andrew C Braisted and James A. Wells},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 19},
  pages={10080-5}
}
The affinity between molecules depends both on the nature and presentation of the contacts. Here, we observe coupling of functional and structural elements when a protein binding domain is evolved to a smaller functional mimic. Previously, a 38-residue form of the 59-residue B-domain of protein A, termed Z38, was selected by phage display. Z38 contains 13… CONTINUE READING