Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri.

@article{Hamiaux2006StructuralMF,
  title={Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri.},
  author={Cyril Hamiaux and Andr{\'e} van Eerde and Claude Parsot and Jaap Broos and Bauke W Dijkstra},
  journal={EMBO reports},
  year={2006},
  volume={7 8},
  pages={794-9}
}
Invasion of epithelial cells by Shigella flexneri is characterized by cytoskeletal rearrangements of the host cell membrane, promoting internalization of the bacterium. The bacterial effector IpaA is injected into the epithelial cell by a type III secretion apparatus and recruits vinculin to regulate actin polymerization at the site of entry. We analysed the complex formed between a carboxy-terminal fragment of IpaA (IpaA(560-633)) and the vinculin D1 domain (VD1), both in crystals and in… CONTINUE READING
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