Structural microtubule cap: stability, catastrophe, rescue, and third state.

  title={Structural microtubule cap: stability, catastrophe, rescue, and third state.},
  author={Imre M. J{\'a}nosi and Denis Chr{\'e}tien and Henrik Flyvbjerg},
  journal={Biophysical journal},
  volume={83 3},
Microtubules polymerize from GTP-liganded tubulin dimers, but are essentially made of GDP-liganded tubulin. We investigate the tug-of-war resulting from the fact that GDP-liganded tubulin favors a curved configuration, but is forced to remain in a straight one when part of a microtubule. We point out that near the end of a microtubule, the proximity of the end shifts the balance in this tug-of-war, with some protofilament bending as result. This somewhat relaxes the microtubule lattice near its… CONTINUE READING

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