Structural metals in the group I intron: a ribozyme with a multiple metal ion core.

@article{Stahley2007StructuralMI,
  title={Structural metals in the group I intron: a ribozyme with a multiple metal ion core.},
  author={Mary R. Stahley and Peter L. Adams and Jimin Wang and Scott A Strobel},
  journal={Journal of molecular biology},
  year={2007},
  volume={372 1},
  pages={
          89-102
        }
}
Metal ions play key roles in the folding and function for many structured RNAs, including group I introns. We determined the X-ray crystal structure of the Azoarcus bacterial group I intron in complex with its 5' and 3' exons. In addition to 222 nucleotides of RNA, the model includes 18 Mg(2+) and K(+) ions. Five of the metals bind within 12 A of the scissile phosphate and coordinate the majority of the oxygen atoms biochemically implicated in conserved metal-RNA interactions. The metals are… CONTINUE READING
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