Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study.

@article{Nikiforovich2012StructuralMO,
  title={Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: molecular modeling study.},
  author={Gregory V. Nikiforovich and Thomas J Baranski},
  journal={Proteins},
  year={2012},
  volume={80 1},
  pages={
          71-80
        }
}
Previously we demonstrated by random saturation mutagenesis a set of mutations in the extracellular (EC) loops that constitutively activate the C5a receptor (C5aR) (Klco et al., Nat Struct Mol Biol 2005;12:320-326; Klco et al., J Biol Chem 2006;281:12010-12019). In this study, molecular modeling revealed possible conformations for the extracellular loops of the C5a receptors with mutations in the EC2 loop or in the EC3 loop. Comparison of low-energy conformations of the EC loops defined two… CONTINUE READING

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