Structural mechanisms of PriA-mediated DNA replication restart.

  title={Structural mechanisms of PriA-mediated DNA replication restart.},
  author={Basudeb Bhattacharyya and Nicholas P. George and Tiffany M Thurmes and Ruobo Zhou and Niketa Jani and Sarah R Wessel and Steven J. Sandler and Taekjip Ha and James L Keck},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 4},
Collisions between cellular DNA replication machinery (replisomes) and damaged DNA or immovable protein complexes can dissociate replisomes before the completion of replication. This potentially lethal problem is resolved by cellular "replication restart" reactions that recognize the structures of prematurely abandoned replication forks and mediate replisomal reloading. In bacteria, this essential activity is orchestrated by the PriA DNA helicase, which identifies replication forks via… CONTINUE READING

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