Structural mechanism of GPCR-arrestin interaction: recent breakthroughs.


G protein-coupled receptors (GPCRs) are a major membrane receptor family with important physiological and pathological functions. In the classical signaling pathway, ligand-activated GPCRs couple to G proteins, thereby inducing G protein-dependent signaling pathways and phosphorylation by G protein-coupled receptor kinases (GRKs). This leads to an… (More)
DOI: 10.1007/s12272-016-0712-1


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