Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.

@article{Li2017StructuralMF,
  title={Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.},
  author={Chun-yang Li and Xiu-lan Chen and Dian Zhang and Peng Wang and Qi Sheng and Ming Peng and Bin-Bin Xie and Qi-Long Qin and Ping-Yi Li and Xi-ying Zhang and Hai-nan Su and Xiao-yan Song and Mei Shi and Bai-cheng Zhou and Lu-ying Xun and Yin Chen and Yu-Zhong Zhang},
  journal={Molecular microbiology},
  year={2017},
  volume={103 6},
  pages={
          992-1003
        }
}
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is responsible for converting TMA to TMAO. However, the molecular mechanism of TMA oxygenation by Tmm has not been explained. Here, we determined the crystal structures of two reaction intermediates of a marine bacterial Tmm (RnTmm) and elucidated… CONTINUE READING
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