Structural mapping of spliceosomes by electron microscopy.

  title={Structural mapping of spliceosomes by electron microscopy.},
  author={Reinhard L{\"u}hrmann and Holger Stark},
  journal={Current opinion in structural biology},
  volume={19 1},
Eukaryotic genes are transcribed as pre-mRNAs which are interrupted by noncoding introns. Selection and accurate removal of introns is an essential step in gene expression that is performed by a large and highly dynamic macromolecular machine, called spliceosome. A major challenge for structural studies of the spliceosome is represented by its large size as well as its dynamic nature. Electron microscopy is an important technique to study the overall shape and architecture of spliceosomes and… CONTINUE READING

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