Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.

@article{Strunnikov1999StructuralMO,
  title={Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.},
  author={Alexander Strunnikov and Rolf Jessberger},
  journal={European journal of biochemistry},
  year={1999},
  volume={263 1},
  pages={6-13}
}
The evolutionarily-conserved eukaryotic SMC (structural maintenance of chromosomes) proteins are ubiquitous chromosomal components in prokaryotes and eukaryotes. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. The two most prominent and best-characterized complexes are cohesin and condensin, necessary for sister chromatid… CONTINUE READING

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