Structural links to kinesin directionality and movement

@article{Wade2000StructuralLT,
  title={Structural links to kinesin directionality and movement},
  author={Richard H. Wade and Frank Kozielski},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={456-460}
}
The kinesin motor proteins generate directional movement along microtubules and are involved in many vital processes, including cell division, in eukaryotes. The kinesin superfamily is characterized by a conserved motor domain of ∼320 residues. Dimeric constructs of N and C class kinesins, with the motor domains at opposite ends of the heavy chain, move towards microtubule plus and minus ends, respectively. Their crystal structures differ mainly in the region linking the motor domain core to… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

evidence that ncd is not processive

K. A. Foster, Gilbert, S. P. Kinetic studies of dimeric ncd
  • Biochemistry 39, 1782–1791
  • 2000

Formation of the compact conformer of kinesin requires a Cterminal heavy chain domain and inhibits microtubule-stimulated ATPase activity

Stock, M.F
  • J. Biol
  • 1999

Motility of ncd on a metal - chelating surfactant : evidence that ncd is not processive

M. J. deCastro, C.-H. Ho, J. StewartR.
  • Biochemistry
  • 1999