Structural lability in stem-loop 1 drives a 5' UTR-3' UTR interaction in coronavirus replication.

@article{Li2008StructuralLI,
  title={Structural lability in stem-loop 1 drives a 5' UTR-3' UTR interaction in coronavirus replication.},
  author={Lichun Li and Hyojeung Kang and Pinghua Liu and Nick Makkinje and Shawn T Williamson and Julian L. Leibowitz and David P Giedroc},
  journal={Journal of molecular biology},
  year={2008},
  volume={377 3},
  pages={790-803}
}
The leader RNA of the 5' untranslated region (UTR) of coronaviral genomes contains two stem-loop structures denoted SL1 and SL2. Herein, we show that SL1 is functionally and structurally bipartite. While the upper region of SL1 is required to be paired, we observe strong genetic selection against viruses that contain a deletion of A35, an extrahelical nucleotide that destabilizes SL1, in favor of genomes that contain a diverse panel of destabilizing second-site mutations, due to introduction of… CONTINUE READING

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