Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ

Abstract

Nucleophosmin (NPM1) is a multifunctional nucleolar protein implicated in ribogenesis, centrosome duplication, cell cycle control, regulation of DNA repair and apoptotic response to stress stimuli. The majority of these functions are played through the interactions with a variety of protein partners. NPM1 is frequently overexpressed in solid tumors of… (More)
DOI: 10.1038/oncsis.2017.78

8 Figures and Tables

Topics

  • Presentations referencing similar topics