Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

@inproceedings{Stavrinides2016StructuralIO,
  title={Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity},
  author={Anna K Stavrinides and Evangelos C Tatsis and Lorenzo Caputi and Emilien Foureau and Clare E M Stevenson and David M. Lawson and Vincent Courdavault and Sarah E O'Connor},
  booktitle={Nature communications},
  year={2016}
}
Plants produce an enormous array of biologically active metabolites, often with stereochemical variations on the same molecular scaffold. These changes in stereochemistry dramatically impact biological activity. Notably, the stereoisomers of the heteroyohimbine alkaloids show diverse pharmacological activities. We reported a medium chain dehydrogenase/reductase (MDR) from Catharanthus roseus that catalyses formation of a heteroyohimbine isomer. Here we report the discovery of additional… CONTINUE READING
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