Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells

@article{MacGrogan2004StructuralIA,
  title={Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells},
  author={Donal MacGrogan and Nagesh Kalakonda and Sara {\'A}lvarez and Joseph M. Scandura and Piernicola Boccuni and Bertil Johansson and Stephen D. Nimer},
  journal={Genes},
  year={2004},
  volume={41}
}
The human L3MBTL gene is located in 20q12, a region that is commonly deleted in myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). L3MBTL is highly homologous to the D‐lethal(3) malignant brain tumor [D‐l(3)mbt] gene, which is a putative tumor‐suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs on midleg (SCM) protein, a member of the Polycomb group (PcG) family of transcriptional repressors… Expand
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TLDR
H-L(3)MBT is a transcriptional repressor and that its activity is largely dependent on the presence of a region containing the three MBT repeats, and the ability of TEL to repress TEL-responsive promoters is enhanced by the absence of H-L (3) MBT, suggesting that histone deacetylase-independent transcriptional repression by TEL depends on the recruitment of PcG proteins. Expand
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