Structural insights into yeast septin organization from polarized fluorescence microscopy

@article{Vrabioiu2006StructuralII,
  title={Structural insights into yeast septin organization from polarized fluorescence microscopy},
  author={Alina M. Vrabioiu and Timothy J Mitchison},
  journal={Nature},
  year={2006},
  volume={443},
  pages={466-469}
}
Septins are polymerizing GTPases that function in cortical organization and cell division. In Saccharomyces cerevisiae they localize at the isthmus between the mother and the daughter cells, where they undergo a transition from a non-dynamic hourglass-shaped assembly to two separate rings, at the onset of cytokinesis. Septins form filaments as pure protein and in vivo, but the filament organization within the hourglass and ring structures is controversial. Here, we use polarized fluorescence… CONTINUE READING