Structural insights into transcription initiation by yeast RNA polymerase I

  title={Structural insights into transcription initiation by yeast RNA polymerase I},
  author={Yashar Sadian and Lucas Tafur and Jan Kosinski and Arjen J Jakobi and Ren{\'e} Wetzel and Katarzyna Buczak and Wim J H Hagen and Michael Beck and Carsten Sachse and Christoph W M{\"u}ller},
  booktitle={The EMBO journal},
In eukaryotic cells, RNA polymerase I (Pol I) synthesizes precursor ribosomal RNA (pre-rRNA) that is subsequently processed into mature rRNA. To initiate transcription, Pol I requires the assembly of a multi-subunit pre-initiation complex (PIC) at the ribosomal RNA promoter. In yeast, the minimal PIC includes Pol I, the transcription factor Rrn3, and Core Factor (CF) composed of subunits Rrn6, Rrn7, and Rrn11. Here, we present the cryo-EM structure of the 18-subunit yeast Pol I PIC bound to a… CONTINUE READING
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