Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.

Abstract

Thyroid hormones (THs) are transported across cell membranes by different transmembrane transporter proteins. In previous studies, we showed marked 3,3'-diiodothyronine (3,3'-T2) but moderate T3 uptake by the L-type amino acid transporter 2 (Lat2). We have now studied the structure-function relationships of this transporter and TH-like molecules. Our Lat2… (More)
DOI: 10.1210/me.2015-1044

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