Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63.

@article{Kurakata2008StructuralII,
  title={Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63.},
  author={Yuma Kurakata and Akiko Uechi and Hiromi Yoshida and Shigehiro Kamitori and Yoshiyuki Sakano and Atsushi Nishikawa and Takashi Tonozuka},
  journal={Journal of molecular biology},
  year={2008},
  volume={381 1},
  pages={116-28}
}
Proteins belonging to the glycoside hydrolase family 63 (GH63) are found in bacteria, archaea, and eukaryotes. Eukaryotic GH63 proteins are processing *-glucosidase I enzymes that hydrolyze an oligosaccharide precursor of eukaryotic N-linked glycoproteins. In contrast, the functions of the bacterial and archaeal GH63 proteins are unclear. Here we determined the crystal structure of a bacterial GH63 enzyme, Escherichia coli K12 YgjK, at 1.78 A resolution and investigated some properties of the… CONTINUE READING
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