Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.

@article{Schmeing2005StructuralII,
  title={Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.},
  author={T. Martin Schmeing and Kevin S. Huang and David E Kitchen and Scott A Strobel and Thomas A Steitz},
  journal={Molecular cell},
  year={2005},
  volume={20 3},
  pages={437-48}
}
Peptide bond formation is catalyzed at the peptidyl transferase center (PTC) of the large ribosomal subunit. Crystal structures of the large ribosomal subunit of Haloarcula marismortui (Hma) complexed with several analogs that represent either the substrates or the transition state intermediate of the peptidyl transferase reaction show that this reaction… CONTINUE READING