Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy

@article{Lv2016StructuralII,
  title={Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy},
  author={M. Lv and Chongyuan Wang and F. Li and Junhui Peng and Bin Wen and Q. Gong and Y. Shi and Yajun Tang},
  journal={Protein & Cell},
  year={2016},
  volume={8},
  pages={25 - 38}
}
Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis. Mitophagy is regulated by the post-translational modification of mitophagy receptors. Fun14 domain-containing protein 1 (FUNDC1) was reported to be a new receptor for hypoxia-induced mitophagy in mammalian cells and interact with microtubule-associated protein light chain 3 beta (LC3B) through its LC3 interaction region (LIR). Moreover, the phosphorylation modification… Expand
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