Structural insights into the promiscuity and function of the human pregnane X receptor.

@article{Watkins2002StructuralII,
  title={Structural insights into the promiscuity and function of the human pregnane X receptor.},
  author={Ryan E Watkins and Schroeder M Noble and Matthew R. Redinbo},
  journal={Current opinion in drug discovery & development},
  year={2002},
  volume={5 1},
  pages={150-8}
}
The pregnane X receptor (PXR) is a promiscuous nuclear receptor that responds to a wide variety of drugs, xenobiotics and endogenous compounds, and plays a critical role in mediating drug-drug interactions in humans. PXR is the master regulator of the expression of the CYP3A4 gene, which encodes for the most abundant and promiscuous drug-metabolizing enzyme in humans. PXR also regulates the expression of other genes involved in xenobiotic metabolism, including CYP2C8, CYP2C9, CYP2B6, GSTA2 and… CONTINUE READING