Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1

@article{Wang2014StructuralII,
  title={Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1},
  author={Jie Wang and Jianjun Jiang and Jue Wang and Lei Chen and Shi-Long Fan and Jia-wei Wu and Xuelu Wang and Zhi-xin Wang},
  journal={Cell Research},
  year={2014},
  volume={24},
  pages={1328-1341}
}
Brassinosteroids (BRs) are essential steroid hormones that have crucial roles in plant growth and development. BRs are perceived by the cell-surface receptor-like kinase brassinosteroid insensitive 1 (BRI1). In the absence of BRs, the cytosolic kinase domain (KD) of BRI1 is inhibited by its auto-inhibitory carboxyl terminus, as well as by interacting with an inhibitor protein, BRI1 kinase inhibitor 1 (BKI1). How BR binding to the extracellular domain of BRI1 leads to activation of the KD and… CONTINUE READING
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