Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B.

@article{Edmondson2007StructuralII,
  title={Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B.},
  author={Dale E. Edmondson and Claudia Binda and Andrea Mattevi},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={464 2},
  pages={269-76}
}
Due to their pharmacological importance in the oxidation of amine neurotransmitters, the membrane-bound flavoenzymes monoamine oxidase A and monoamine oxidase B have attracted numerous investigations and, as a result, two different mechanisms; the single electron transfer and the polar nucleophilic mechanisms, have been proposed to describe their catalytic mechanisms. This review compiles the recently available structural data on both enzymes with available mechanistic data as well as current… CONTINUE READING

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