Structural insights into the degradation of Mcl-1 induced by BH 3 domains

@inproceedings{Czabotar2007StructuralII,
  title={Structural insights into the degradation of Mcl-1 induced by BH 3 domains},
  author={Peter E. Czabotar and Erinna F. Lee and Mark F. van Delft and Catherine L Day and Brian J Smith and David C S Huang and Walter Douglas Fairlie and Mark G. Hinds and Peter M. Colman},
  year={2007}
}
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the threedimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C… CONTINUE READING
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