Structural insights into the catalysis and regulation of E3 ubiquitin ligases

  title={Structural insights into the catalysis and regulation of E3 ubiquitin ligases},
  author={Lori Buetow and Danny T. Huang},
  journal={Nature Reviews Molecular Cell Biology},
Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates governs numerous eukaryotic cellular processes, including apoptosis, cell division and immune responses. Ubiquitylation was originally associated with protein degradation, but it is now clear that ubiquitylation also mediates processes such as protein–protein interactions and cell signalling depending on the type of ubiquitin conjugation. Ubiquitin ligases (E3s) catalyse the final step of ubiquitin… CONTINUE READING
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